the effect of different training modes on serum apelin and pain threshold in morphine-dependent rats

Authors

ebrahim zarrinkalam department of exercise physiology, faculty of physical education and sport science, bu ali sina university, hamadan, ir iran

ali heidarianpour department of exercise physiology, faculty of physical education and sport science, bu ali sina university, hamadan, ir iran; department of exercise physiology, faculty of physical education and sport science, bu ali sina university, hamadan, ir iran. tel: +98-9188187984

abstract

conclusions the results showed that endurance training reduced pain by increasing apelin in morphine-dependent rats. therefore, it is suggested that this type of training be considered for the morphine-dependent patients for pain relief. objectives therefore, the aim of this study was to evaluate apelin and pain threshold changes in healthy and morphine-dependent rats in response to two exercise paradigms. materials and methods in this study, 30 healthy and 30 morphine-dependent rats were used. morphine-dependent and healthy rats were divided into six groups: 1, a control (healthy) group; 2, a healthy endurance group; 3, a healthy strength-training group; 4, an addicted control group; 5, an addicted endurance group; 6, an addicted strength-training group. then, the training groups performed aerobic and strength training for eight weeks. after the training program, the tail flick and formalin tests were used to assess pain. apelin was also measured by elisa. results regardless of the type of exercise, exercise significantly increased the apelin serum levels in healthy rats. the apelin levels significantly increased in the morphine-dependent rats compared with the healthy control group. endurance, unlike strength training, significantly increased apelin in the serum compared to the addicted control group. the training led to pain relief in the morphine-dependent rats and returned it to the healthy control group level. the pearson correlation showed a reverse significant correlation between the serum apelin level and the tail flick test in the morphine-dependent rats. background apelin has recently been identified as an analgesic agent and a novel neuropeptide. on the other hand, it has been shown that exercise can lead to reduced pain in morphine-dependent patients.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

The Effect of Different Training Modes on Serum Apelin and Pain Threshold in Morphine-Dependent Rats

Background: Apelin has recently been identified as an analgesic agent and a novel neuropeptide. On the other hand, it has been shown that exercise can lead to reduced pain in morphine-dependent patients. Objectives: Therefore, the aim of this study was to evaluate apelin and pain threshold changes in healthy and morphine-dependent rats in response to two exercise paradigms. Materials and Method...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Effect of 8-Week Aerobic, Strength and Concurrent Training on Circulating Apelin in Morphine-Dependent Rats

  ABSTRACT         Background and Objectives: Previous studies have shown that morphine dependence leads to myocardial dysfunction. In addition, apelin plays a protective role in cardiac function. The purpose of this study was to evaluate effects of morphine dependence and three models of exercise training on serum apelin level of dependent and healthy ...

full text

the effect of oxytetracycline on serum calcium, phosphorus and magnesium in cattle

نتایج این مطالعه نشان می دهد که مقدار کلسیم (یونیزه و تام)، منیزیم و فسفر به طور معنی داری تغییر پیدا کرد به جزء مقدار کلسیم تام و منیزیم در روش داخل عضلانی که تغییر معنی داری نداشته است. بر اساس نتایج این مطالعه می توان نتیجه گیری کرد که اکسی تتراساکلین بر روی مقادیر سرمی کلسیم و منیزیم تأثیر می گذارد باید مقدار این کاتیون ها در بیماران، در هنگامی که اکسی تتراسایکلین استفاده می شود مورد توجه ق...

15 صفحه اول

the effect of aerobic exercise training on plasma apelin levels and pain threshold in t1dm rats

conclusions these findings suggest that apelin does not play any significant role in regulating the pain threshold in type 1 diabetes mellitus during exercise training. results plasma apelin level was higher (0.3 vs. 0.1, p < 0.0001) and the tail-flick latency was lower (2.2 vs. 3.8, p < 0.0001) in the d group than in the nd group. after the training program, plasma apelin levels decreased in t...

full text

Effects of regular swimming exercise on the pain threshold following withdrawal syndrome in morphine-dependent rats

Introduction: Nowadays Opioids are gaining acceptance for the management of moderate to severe and chronic pain. In addition, a number of studies have shown that plasma levels of β-endorphin (βEP) in exercise trained are higher than sedentary rats. In our study we assume that exercise training can reduce pain after withdrawal syndrome in morphine-dependent rats. Methods: Male Wistar rats (2...

full text

My Resources

Save resource for easier access later


Journal title:
avicenna journal of neuro psycho physiology

جلد ۲، شماره ۳، صفحات ۰-۰

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023